The specific regions of the brain are integrated in extended functional systems. Two neuroscience scholars, Gerald Edelman and Antonio Damasio, have proposed comprehensive theoretical accounts of these brain systems. Their ideas contribute to a global understanding of the interaction of sensory and motor systems, emotion, memory and consciousness. Gerald Edelman, in collaboration with his younger colleague Giulio Tononi, has summed up his ideas in A Universe of Consciousness. How Matter Becomes Imagination (2000). Antonio Damasio has gathered his neuroscientific insight in Self Comes to Mind. Constructing the Conscious Brain (2010).